Preimplantation diagnosis of the aneuploidies most commonly found in spontaneous abortions and live births: XY, 13, 14, 15, 16, 18, 21, 22
- 1 December 1998
- journal article
- research article
- Published by Wiley in Prenatal Diagnosis
- Vol. 18 (13) , 1459-1466
- https://doi.org/10.1002/(sici)1097-0223(199812)18:13<1459::aid-pd514>3.0.co;2-v
Abstract
The present preimplantation diagnosis test is able to screen for the most common aneuploidies from single blastomeres in about five hours with a 15 per cent misdiagnosis. This means that the risk of spontaneous abortion and trisomic offspring for women of advanced maternal age could be reduced to the same level as younger women for whom prenatal diagnosis is usually not necessary. Better probes and more fluorochromes could improve the success rate of the test. Copyright © 1998 John Wiley & Sons, Ltd.Keywords
This publication has 27 references indexed in Scilit:
- Chromosome Abnormalities in Embryos Obtained After Conventional In Vitro Fertilization and Intracytoplasmic Sperm InjectionFertility and Sterility, 1998
- First Pregnancies After Preconception Diagnosis of Translocations of Maternal OriginFertility and Sterility, 1998
- Polar body diagnosis of common aneuploidies by FISHJournal of Assisted Reproduction and Genetics, 1996
- Reduction in signal overlap results in increased FISH efficiency: Implications for preimplantation genetic diagnosisJournal of Assisted Reproduction and Genetics, 1996
- Simultaneous enumeration of chromosomes 13, 18, 21, X, and Y in interphase cells for preimplantation genetic diagnosis of aneuploidyCytogenetic and Genome Research, 1996
- Detection of sex chromosomal aneuploidies X‐X, Y‐Y, and X‐Y in human sperm using two‐chromosome fluorescence in situ hybridizationAmerican Journal of Medical Genetics, 1994
- A fast and efficient method for simultaneous X and Y in situ hybridization of human blastomeresJournal of Assisted Reproduction and Genetics, 1993
- Dual fluorescent in situ hybridisation for simultaneous detection of X and Y chromosome-specific probes for the sexing of human preimplantation embryonic nucleiHuman Genetics, 1992
- The early lethality of autosomal monosomy in the mouseJournal of Experimental Zoology, 1985
- Maternal age-specific rates of numerical chromosome abnormalities with special reference to trisomyHuman Genetics, 1985