Rate‐controlled rectal absorption enhancement of cefoxitin by co‐ administration of sodium salicylate or sodium octanoate in healthy volunteers.

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Abstract
1. The effects of sodium octanoate and sodium salicylate on the rectal absorption of cefoxitin were investigated in healthy volunteers. Drug solutions were given either as a bolus or as a zero‐order infusion. 2. On rectal infusion sodium octanoate and sodium salicylate both enhanced mean cefoxitin bioavailability (+/‐ s.d.) from 5.0 +/‐ 1.2% to 9.1 +/‐ 1.3% and 9.2 +/‐ 1.5%, respectively. After rectal bolus delivery octanoate increased the mean cefoxitin bioavailability from 7 +/‐ 3% to 17 +/‐ 3%, whereas bolus salicylate did not produce a statistically significant effect. All formulations were well tolerated by the volunteers. 3. It is concluded that both octanoate and salicylate are capable of enhancing rectal cefoxitin absorption in man; rate of delivery seems to be an important factor.

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