Metabolic fate of indeloxazine hydrochloride: α-glucoside formation in rats
- 1 January 1988
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 18 (2) , 141-149
- https://doi.org/10.3109/00498258809041650
Abstract
1. After oral administration of indeloxazine hydrochloride ((.+-.)-2-[(inden-7-yloxy)methyl]morpholine hydrochloride) to rats, two conjugates, which were labile to .alpha.-glucosidase hydrolysis but refractory to .beta.-glucosidase, were isolated from the urine. 2. Mass spectral and n.m.r. analyses confirmed that these conjugates were .alpha.-D-glucopyranosides of M-2 (trans-4-(2-morpholinylmethoxy)-1,2-indandiol) and M-3 (trans-6-[[(1,2-dihydroxy-4-indanyl)oxy]-methyl]-3-morpholinone). 3. These are probably the first examples of foreign compounds conjugated with glucose in the .alpha.-configuration.This publication has 12 references indexed in Scilit:
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