Experimental Models for the Study of Prostatic Adenocarcinoma
- 1 July 1977
- journal article
- research article
- Published by Wolters Kluwer Health in Journal of Urology
- Vol. 118 (1 Part 2) , 216-220
- https://doi.org/10.1016/s0022-5347(17)57949-5
Abstract
The Dunning R3327H transplantable rat tumor is a well differentiated prostatic adenocarcinoma. The biological properties of this tumor were characterized, and it appears that this animal model is well suited for studying the nature of prostatic cancer. The established tumor responds to castration therapy and this is subsequently followed by relapse to a predominant state of hormone insensitivity. Cell kinetic studies indicate that 70-90% of tumor cells are hormonally sensitive, and a subpopulation of 8-30% are hormone insensitive. The therapeutic relapse to androgen deprivation represents the continued growth of the clone of cells, which were hormone insensitive. It appears that this animal tumor mimics the relapse phenomenon observed in the hormone control of human prostatic cancer.This publication has 2 references indexed in Scilit:
- Polymerization of deoxyribonucleotides in relation to androgen-induced prostatic growthArchives of Biochemistry and Biophysics, 1968
- Studies on the Growth of Cells. The Cultivation of Bladder and Prostatic Tumors Outside The BodyJournal of Urology, 1917