RADIOIMMUNOASSAY FOR HUMAN-PLASMA 8-ARGININE-VASOPRESSIN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 38  (1) , 61-72
Abstract
A radioimmunoassay for human plasma vasopressin (AVP), which permits the estimation of antidiuretic hormone (ADH) levels as low as 0.8 pg/ml, was developed. Average plasma level of AVP after overnight water restriction was 14.3 pg/ml (SD = 4.4 pg/ml) in normal subjects. Hypersecretion of ADH was induced by injection of 1-2 mg nicotine. In 11 volunteer normal subjects this nicotine stimulation provoked ADH hypersecretion which reached a maximum between 2nd-15th min after injection. In 3 cases of diabetes insipidus, nicotine injection did not induced ADH hypersecretion; in 1 case of potomania this response was weak; in 2 cases of syndrome of inappropriate ADH secretion, AVP plasma levels were elevated, and the response after nicotine stimulation was exaggerated.

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