Control of phosphatidylcholine synthesis and the regulatory role of choline kinase in rat liver. Evidence from essential-fatty acid-deficient rats

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Abstract
Choline kinase [EC 2.7.1.32] and phosphocholine cytidylyltransferase [EC 2.7.7.15] catalyze the rate-limiting steps of the cytidine pathway for the synthesis of phosphatidylcholine. Essential-fatty acid deficiency induced a 3.5-fold increase in the specific activity of choline kinase, whereas the specific activity of the cytidylyltransferase remained unchanged in rat liver. This change in specific activity accounted for the calculated increase in flux through the cytidine pathway produced in vivo by the same dietary state, confirming the fact that choline kinase has a regulatory role in the cytidine pathway for the synthesis of phosphatidylcholine.