Asymmetric Catalytic Hydrosilylation of Ketones with Triethoxysilane Using a Chiral Binaphthol-Titanium Complex
- 31 December 1996
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1996 (12) , 1229-1230
- https://doi.org/10.1055/s-1996-5726
Abstract
The asymmetric catalytic hydrosilylation of prochiral ketones with HSi(OEt)3 using (R)-BINOL-Ti(O-i-Pr)2 as a precatalyst is shown to proceed in excellent yields. Although the observed levels of enantioselectivity were moderate (up to 55% ee), an interesting phenomenon of ”enantioselective autoinduction” was observed.Keywords
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