COPPER BENZOCHLORIN, A NOVEL PHOTOSENSITIZER FOR PHOTODYNAMIC THERAPY: EFFECTS ON A TRANSPLANTABLE UROTHELIAL TUMOR
- 1 April 1993
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 57 (4) , 681-685
- https://doi.org/10.1111/j.1751-1097.1993.tb02937.x
Abstract
Abstract— An iminum salt of octaethylbenzochlorin with copper in the aromatic ring, CDSI, was tested for its tumoricidal effects on theA–27 N‐[4‐(5‐notro‐2‐furyl)‐2‐thiazoly] formamide tumor line. CDSI was found to be an effective photosensitiz4r in vivo when used in combination with either a xenon arc lamp or a pulsed alexandrite laser. Hemodynamically, CDSI and light caused a rapid decrease in tumor blood flow. skin photosensitization was found to be minimal when drug‐injected mice werwe illuminated in a solar simulator.Keywords
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