Soluble Antigens and Antibodies in Sera from Baboons Infected with Schistosoma mansoni

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Abstract
Summary: Sera from baboons (Papio anubis) exposed percutaneously to S. mansoni cercariae were examined for the presence of antigens and antibodies at different times after infection by counter-current immunoelectrophoresis. The first antigens detected were gut-associated antigens (2 to 4 weeks after infection) followed by membrane antigens (3 to 5 weeks) and soluble egg antigens (7 weeks). Corresponding antibodies were detected 1 to 2 weeks later. The possibility that the simultaneous detection of both components in serum strongly suggests the presence of circulating immune complexes is discussed.

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