MODELING RHODOPSIN, A MEMBER OF G‐PROTEIN COUPLED RECEPTORS, BY COMPUTER GRAPHICS. INTERPRETATION OF CHEMICAL SHIFTS OF FLUORINATED RHODOPSINS
- 1 December 1992
- journal article
- Published by Wiley in Photochemistry and Photobiology
- Vol. 56 (6) , 883-893
- https://doi.org/10.1111/j.1751-1097.1992.tb09709.x
Abstract
Abstract— An attempt has been made to construct a 3‐D model of rhodopsin, a member of G‐protein coupled receptors. Sequence homology of rhodopsin with the latter was a factor considered in the modeling procedure. The constructed model has been used to compare currently available specific protein/substrate interaction information, the shape of the binding cavity derived from shape of binding retinal isomers and analogs and challenged to explain recently available results from a series of fluorinated rhodopsins.Keywords
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