Neutron diffraction from crystals of nucleosome core particles
Open Access
- 20 November 1980
- journal article
- Published by The Royal Society in Philosophical Transactions of the Royal Society of London. B, Biological Sciences
- Vol. 290 (1043) , 635-638
- https://doi.org/10.1098/rstb.1980.0122
Abstract
The nucleosome is the basic repeating unit of chromatin (see review by Kornberg (1977)). It is a complex of histone protein molecules with a length of DNA, which digestion studies with the enzyme micrococcal nuclease have shown to be often about 200 base pairs in length but with quite wide variations between different cell species. With sufficient digestion, however, a ‘core’ particle is produced, which for all species so far investigated contains close to 145 base pairs of DNA associated with an octamer of pairs of the histones H3, H4, H2A and H2B. The molecular mass of the core particle is about 200000, roughly equally divided between DNA and protein.Keywords
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