Nickel-Catalyzed Cross-Coupling Reaction of Aryl Halides in Pyridine. A Practical Synthesis of 4′-Methylbiphenyl-2-carbonitrile As a Key Intermediate of Angiotensine II Receptor Antagonists
- 1 January 1994
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1994 (05) , 371-372
- https://doi.org/10.1055/s-1994-22858
Abstract
The title reaction was found to afford unsymmetrical biphenyl derivatives little less than 70% selectivity, which was strongly depended on the aryl halides employed. 4′-Methyl-1,1′-biphenyl-2-carbonitrile was isolated in 59% yield as a pure state by a simple crosscoupling reaction of 4-bromotoluene and 2-chlorobenzonitrile.Keywords
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