The Reactivity–Selectivity Principle: An Imperishable Myth in Organic Chemistry
- 6 March 2006
- journal article
- review article
- Published by Wiley in Angewandte Chemie International Edition in English
- Vol. 45 (12) , 1844-1854
- https://doi.org/10.1002/anie.200503273
Abstract
The reactivity–selectivity principle (RSP), once a tenet of organic chemistry, eroded during the 1970s and was more or less abandoned by 1980. Although it has been clear for more than 25 years that a decrease in selectivity with increasing reactivity can only be expected with certainty if diffusion control is approached, the RSP has survived as an intuitively appealing rule. This Minireview shows why selectivity cannot generally decrease with increasing reactivity and highlights the weaknesses of the theoretical foundations of the RSP.This publication has 143 references indexed in Scilit:
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