An Improved Trace Analysis for N-Nitrosoureas from Biological Media
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 5 (1) , 42-46
- https://doi.org/10.1093/jat/5.1.42
Abstract
1,3-Bis(2-chloroethyl)-1-nitrosourea, BCNU, a widely used anticancer agent for a variety of neoplasms, can be rapidly, conveniently, and inexpensively determined at trace levels of clinical importance, from a variety of biological media, using HPLC-UV approaches. Limits of detection for BCNU from patient and control samples have been compared for HPLC-UV, HPLC-EC, and the Griess Test. The distribution and disappearance of BCNU from blood samples can be quickly and easily determined using the methods described. Individual blood samples are completely analyzed in less than 30 mins, from the time of sampling to qualitative and quantitative results.This publication has 6 references indexed in Scilit:
- COMPARISON OF MUTAGENICITY, ANTI-TUMOR ACTIVITY, AND CHEMICAL PROPERTIES OF SELECTED NITROSOUREAS AND NITROSOAMIDES1979
- Analysis for 1,3-bis(2-chloroethyl)-1-nitrosourea by chemical ionization mass spectrometry.Clinical Chemistry, 1978
- Rapid micromethod for measuring anticonvulsant drugs in serum by high-performance liquid chromatography.Clinical Chemistry, 1976
- Mutagenicity of nitrosamides and nitrosamidines in micro-organisms and plantsMutation Research/Reviews in Genetic Toxicology, 1976
- Mutagenic and carcinogenic N-nitroso compounds: Possible environmental hazardsMutation Research/Reviews in Genetic Toxicology, 1976
- The Antitumor Agent, 1,3-bis(2-chloroethyl)-1-nitrosoureaJournal of Pharmaceutical Sciences, 1966