Cytochrome P-450 metabolic-intermediate complex formation and induction by macrolide antibiotics; a new class of agents
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 12 (11) , 687-699
- https://doi.org/10.3109/00498258209038944
Abstract
1. By several criteria, macrolide antibiotics constitute a new class of nitrogenous cytochrome P-450 metabolic-intermediate complex-forming compounds. 2. Macrolide antibiotic metabolic-intermediate complexes are only formed in livers induced with phenobarbital or with the macrolide antibiotics themselves. The extent of metabolic-intermediate complex formation in microsomes from phenobarbital-induced rats is lower than that seen for members of the amphetamine and SKF 525-A classes of compounds. 3. Cytochrome P-450 induced by macrolide antibiotics, of which troleandomycin is the most potent, is extensively sequestered as a metabolic intermediate complex in vivo 4. Cytochrome P-450 induced by troleandomycin differs, using several criteria, from those induced by phenobarbital, β-naphthoflavone or SKF 525-A, and those present in uninduced rats.This publication has 33 references indexed in Scilit:
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