β‐LIPOTROPIN: PRIMARY STRUCTURE OF THE HORMONE FROM THE OSTRICH PITUITARY GLAND

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Abstract
The amino acid sequence of β‐lipotropin from the ostrich pituitary has been determined. It consists of 79 amino acids. The amino acid 10sequence has been determined as follows: H‐20Ala‐Leu‐Pro‐Pro‐Ala‐Ala‐Met‐Leu‐Pro‐Ala‐30Ala‐Ala‐Glu‐Glu‐Glu‐Glu‐Gly‐Glu‐Glu‐Glu‐40Glu‐Glu‐Gly‐Glu‐Ala‐Glu‐Lys‐Glu‐Asp‐Gly‐50Gly‐Ser‐Tyr‐Arg‐Met‐A rg‐His‐Phe‐Arg‐Trp‐Gln‐60Ala‐Pro‐Leu‐Lys‐Asp‐Lys‐Arg‐Tyr‐Gly‐Gly‐70Phe‐Met‐Ser‐Ser‐Glu‐Arg‐Gly‐Arg‐Ala‐79Pro‐Leu‐Val‐Thr‐Leu‐Phe‐Lys‐Asn‐Ala‐Ile‐Val‐Lys‐Ser‐Ala‐Tyr‐Lys‐Lys‐Gly‐Gln‐OH. When compared with the primary structures of other known β‐lipotropins, the sequence at the NH2‐terminal, β‐melanotropin and β‐endorphin portions of the molecule exhibit considerable variability.