HETEROZYGOUS EXPRESSION OF INSULIN-DEPENDENT DIABETES-MELLITUS (IDDM) DETERMINANTS IN THE HLA SYSTEM
- 1 January 1983
- journal article
- research article
- Vol. 35 (2) , 201-213
Abstract
HLA phenotypes of cases with insulin-dependent diabetes mellitus (IDDM) and identity by descent of HLA haplotypes in affected sib-pairs support an intermediate model in which morbid risk is increased by one HLA-linked IDDM determinant, and greatly increased by 2 determinants, which may be qualitatively different in DR3 and DR4 haplotypes. Linkage analysis allowing for gametic disequilibrium reveals no recombination in pedigrees with a DR3/DR4 propositus, but spurious recombination in the remaining pedigrees. This evidence favors interaction of unlinked IDDM determinants to produce affection in a small proportion of heterozygotes for an HLA-linked determinant. Partition of data by HLA type of the propositus (ideally by DR and the complement types jointly) is a powerful method to resolve etiological heterogeneity for HLA-associated diseases.This publication has 15 references indexed in Scilit:
- CLOSE GENETIC LINKAGE BETWEEN DIABETES MELLITUS AND KIDD BLOOD GROUPThe Lancet, 1981
- Juvenile insulin‐dependent diabetes: a possible susceptibility gene in interaction with HLAAnnals of Human Genetics, 1981
- HLA AND DISEASE - PREDICTIONS FOR HLA HAPLOTYPE SHARING IN FAMILIES1981
- Complex Segregation Analysis with PointersHuman Heredity, 1981
- Resolution of Linkage for Irregular Phenotype SystemsHuman Heredity, 1981
- Gene dosage and susceptibility to insulin‐dependent diabetesAnnals of Human Genetics, 1980
- A two locus model for juvenile diabetesAnnals of Human Genetics, 1980
- A three-allele model for heterogeneity of juvenile onset insulin-dependent diabetesAnnals of Human Genetics, 1980
- Analysis of family resemblance. 3. Complex segregation of quantitative traits.1974
- SEQUENTIAL TESTS FOR THE DETECTION OF LINKAGE1955