Antipicornavirus activity of substituted phenoxybenzenes and phenoxypyridines
- 1 March 1986
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 29 (3) , 427-433
- https://doi.org/10.1021/jm00153a020
Abstract
Phenoxybenzenes and phenoxypyridines were prepared and tested for the effect of substituents on antipicornavirus activity. The most active compound, 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (8), demonstrated broad-spectrum antipicornavirus activity. Compound 8 and several analogues each given orally prior to and during infection protected mice against an othewise lethal challenge with coxsackievirus A21.This publication has 0 references indexed in Scilit: