The effect of mouthrinses and topical application of chlorhexidine on the development of dental plaque and gingivitis in man

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Abstract
Twenty‐four male dental students with healthy gingivae and clean teeth ceased all oral hygiene procedures. (A) Four subjects rinsed, twice daily, with a 0.2 per cent solution of chlorhexidine gluconate; (B) eight students rinsed, once daily, with the same solution; (C) six students did not rinse and formed the control group and (D) six students received one daily application of a 2 per cent solution of chlorhexidine gluconate. The study confirmed previous observations (Löe and Rindom Schiött 1969, 1970) that two daily mouth rinses with a 0.2 per cent solution of chlorhexidine effectively prevent plaque formation. One daily rinse did not inhibit plaque formation in all areas of the dentition. One daily topical application of a 2 per cent solution of chlorhexidine gluconate prevented plaque formation completely. Upon discontinuation of the chlorhexidine treatment plaque formed at normal rates, suggesting that there is no appreciable effect beyond a 24 hour period. It is concluded that complete inhibition of plaque and prevention of gingivitis may be achieved by daily application of chlorhexidine, provided the agent is administered in such a way that it reaches all tooth surfaces.

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