Synaptic release of GABA by AgRP neurons is required for normal regulation of energy balance
Top Cited Papers
- 10 August 2008
- journal article
- research article
- Published by Springer Nature in Nature Neuroscience
- Vol. 11 (9) , 998-1000
- https://doi.org/10.1038/nn.2167
Abstract
Neurons expressing Agouti-related protein (AgRP) and neuropeptide Y (NPY) in the hypothalamus are involved in regulation of feeding and body weight, but genetic disruption of AgRP and NPY have little effect on energy homeostasis. A new study from Tong et al. shows that the energy homeostasis function is mediated through their GABAergic transmission. The physiologic importance of GABAergic neurotransmission in hypothalamic neurocircuits is unknown. To examine the importance of GABA release from agouti-related protein (AgRP) neurons (which also release AgRP and neuropeptide Y), we generated mice with an AgRP neuron–specific deletion of vesicular GABA transporter. These mice are lean, resistant to obesity and have an attenuated hyperphagic response to ghrelin. Thus, GABA release from AgRP neurons is important in regulating energy balance.Keywords
This publication has 15 references indexed in Scilit:
- AgRP in energy balance: Will the real AgRP please stand up?Cell Metabolism, 2006
- NPY/AgRP Neurons Are Essential for Feeding in Adult Mice but Can Be Ablated in NeonatesScience, 2005
- Postembryonic ablation of AgRP neurons in mice leads to a lean, hypophagic phenotypeThe FASEB Journal, 2005
- Anatomy and regulation of the central melanocortin systemNature Neuroscience, 2005
- Orexigenic Action of Peripheral Ghrelin Is Mediated by Neuropeptide Y and Agouti-Related ProteinEndocrinology, 2004
- Leptin Receptor Signaling in POMC Neurons Is Required for Normal Body Weight HomeostasisNeuron, 2004
- The Distribution and Mechanism of Action of Ghrelin in the CNS Demonstrates a Novel Hypothalamic Circuit Regulating Energy HomeostasisNeuron, 2003
- Neither Agouti-Related Protein nor Neuropeptide Y Is Critically Required for the Regulation of Energy Homeostasis in MiceMolecular and Cellular Biology, 2002
- Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleusNature, 2001
- Z/EG, a double reporter mouse line that expresses enhanced green fluorescent protein upon cre-mediated excisionGenesis, 2000