CALCIUM PYROPHOSPHATE CRYSTAL-FORMATION IN AQUEOUS-SOLUTIONS

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  • 1 January 1980
    • journal article
    • research article
    • Vol. 7  (5) , 609-616
Abstract
Pseudogout is characterized by the deposition of calcium pyrophdsphate dihydrate, triclinic [CPPD(T)] and calcium pyrophosphate dihydrate, monoclinic [CPPD(M)] crystals in articular connective tissues. Aqueous solutions were studied over a range of calcium chloride/sodium pyrophosphate concentrations to determine the ionic conditions under which these particular salts form. At 37.degree. C CPPD(T) forms when [PPi]t .gtoreq. 10-4, while formation of CPPD(M) occurs at 10-3 M < [PPi]t .ltoreq. 10-2 M. When [Na+]t ( [total Na+] ) > 120 mM, calcium disodium pyrophosphates precipitate. With 1 mM Mg2+, CPPD(M) forms at [PPi]t > 10-3 M, mixed with a calcium magnesium pyrophosphate at [PPi]t .gtoreq. 10-2 M. CPPD(T) and CPPD(M) crystals form in a restricted ratio and range of [Ca2+]t [total Ca2+] and [PPi]t. Other ions, particularly Mg2+ and Na+, affect the nature of the crystal products formed.

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