RELATIVE HEMODYNAMIC EFFECTIVENESS OF WHOLE-BLOOD AND PLASMA EXPANDERS IN BURNED PATIENTS

  • 1 January 1977
    • journal article
    • research article
    • Vol. 144  (6) , 909-914
Abstract
In a series of 9 fatally burned patients, hemodynamic and O2 transport measurements were made before, during and after 56 administrations of 500 ml of whole blood or colloids and 1000 ml of crystalloids. To enhance comparability, 38 of these studies were conducted at intervals on the same patient, the patient serving as his own control. The data indicate greater hemodynamic responses to colloids than to whole blood and greater responses to whole blood than to crystalloids when the latter was given at twice the volume and at 4 times the volume of the colloid. In addition to replenishing salt and water, restoration of hemodynamic and O2 transport variables may be accomplished by expansion of plasma volume with colloids and whole blood. Adequate nutrition is also needed for the increased metabolic needs of the burned patient. Without supplemental nutrition, high grade plasma proteins and tissue proteins may be expended as energy substrates; the lowering of plasma proteins tends to redistribute water from the plasma to the interstitial phase, which increases further the peripheral edema.

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