The Pathology of Poliomyelitis Experimentally Induced in the Eastern Cotton Rat, Sigmodon hispidus hispidus

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Abstract
The virus of human poliomyelitis produces in the cotton rat a polio-myeloencephalitis which is closely similar in topographic distribution as well as in individual lesion types to that observed in man and Macacus rhesus with this virus. In the brain, medulla and pons show the greatest reaction, cerebellar roof nuclei and midbrain next. Nerve cell necrosis, polymorphonuclear infiltration and invasion of necrotic cells, neuronophagia, focal and diffuse cellular gliosis, and vascular endothelial swelling and proliferation and sheath lymphocyte infiltration are all observed. Other organs show no important changes.

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