The Androgen-Dependent Mouse Seminal Vesicle Secretory Protein IV: Characterization and Complementary Deoxyribonucleic Acid Cloning
Open Access
- 1 October 1987
- journal article
- research article
- Published by The Endocrine Society in Molecular Endocrinology
- Vol. 1 (10) , 707-716
- https://doi.org/10.1210/mend-1-10-707
Abstract
Seminal vesicle secretory protein IV of a mouse has been isolated, and the cDNA coding for its mRNA has been cloned and sequenced. The 556-nucleotides encode 16 amino acid signal peptides and 92 residues of mature protein. Considerable homology between mouse and rat SVS IV cDNA was found. In the leader peptide and 3′-noncoding region there is 92% and 85% homology, respectively. The other regional homologies are 86% for the first 12, 68.5% for the last 35, and 40% for the middle 44 amino acids. The expression of mouse SVS IV mRNA is under the control of androgen. Administration of testosterone to castrated mice resulted in induction of the mRNA level to 50% of the mature male in 96 h of hormone treatment. Secretion of the protein after testosterone injection follows a similar patternKeywords
This publication has 1 reference indexed in Scilit:
- Isolation of recombinant plasmids containing structural gene sequences for rat seminal vesicle secretory proteins IV and VBiochemical and Biophysical Research Communications, 1981