Impact of HIV Infection and HAART on Serum Lipids in Men

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Abstract
Before the availability of highly active antiretroviral therapy (HAART), studies in persons infected with human immunodeficiency virus (HIV) type 1 demonstrated lipid abnormalities. Men with HIV infection were reported to have hypocholesterolemia with and without hypertriglyceridemia.1-4 An association between plasma triglyceride levels and circulating interferon α levels has been observed in persons with AIDS; however, the mechanism for hypocholesterolemia in HIV and other infections is not known.1,2 A pattern of hyperlipidemia (ie, elevated levels of total cholesterol [TC], low-density lipoprotein cholesterol [LDL-C], and triglycerides, and a reduced level of high-density lipoprotein cholesterol [HDL-C]) has been observed in patients treated with protease inhibitors (PIs).5-13