Hazards to Health Workers from Antineoplastic Drugs

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Abstract
The study by Selevan et al. in this issue of the Journal 1 provides documentation that nurses exposed to antineoplastic drugs are at risk of adverse effects on reproduction. Thus, an outcome that could be predicted from the vast amount of research on the biochemical mechanisms of action of these drugs, both in vitro and in vivo, has been demonstrated by the meticulous and arduous techniques of epidemiologists.The story began with the development of chemicals designed to produce cytotoxic effects (hence their efficacy as antineoplastic agents). Next, there were troubling reports in the toxicologic literature on the specific mechanisms of . . .