Estimation of linkage disequilibrium from conditional haplotype data: Application to β‐globin gene cluster in American blacks
- 1 January 1986
- journal article
- research article
- Published by Wiley in Genetic Epidemiology
- Vol. 3 (5) , 323-333
- https://doi.org/10.1002/gepi.1370030505
Abstract
Simple estimators of gene frequencies and linkage disequilibria are proposed when haplotype data are available from four parental chromosomes of a child (or fetus) for whom genetic counseling is sought for a disease condition. The method is illustrated with restriction site polymorphisms associated with sickle-cell anemia (Hb-βS) gene as surveyed in genetic counseling data from American blacks. The method suggested here is shown to be useful in testing for the significance of interactions of site-specific variations of any order in the chromosomal region assayed.Keywords
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