The Effects of Orchidectomy, Estrogens, and Cyproterone Acetate on Plasma Testosterone, LH, and FSH Concentrations in Patients with Carcinoma of the Prostate
- 1 January 1982
- journal article
- research article
- Published by Taylor & Francis in Scandinavian Journal of Urology and Nephrology
- Vol. 16 (1) , 31-36
- https://doi.org/10.3109/00365598209179637
Abstract
The peripheral plasma concentrations of testosterone, luteinising hormone (LH) and follicle stimulating hormone (FSH) were determined in 46 patients (age 51-86 years) with cytologically confirmed prostatic carcinoma. Treatment consisted of subcapsular orchidectomy (15 cases) or estrogen medication (16 cases) or cyproterone acetate (15 cases). The determinations were made before and 2 weeks and 2 months after treatment was initiated. No correlation was found between the pretreatment levels of testosterone and gonadotrophins and the local extent of the primary tumor or the degree of malignancy. Nor was there any correlation between hormonal level, presence of metastases or patient age. Orchidectomy and estrogen medication both resulted in very low plasma testosterone levels, corresponding to 15% of the pretreatment values. This proportion was 28% in the group treated with cyproterone acetate. Orchidectomy was followed by significant increase in the levels of LH and FSH. Estrogen treatment resulted in suppression of the LH levels to 40% and of FSH to 14% of the pretreatment values. The corresponding decreases in response to cyproterone acetate were 65 and 35%. The results indicate that reduction in gonadotrophin secretion is the primary mechanism in the lowering of testosterone levels produced by treatment with estrogens or cyproterone acetate.Keywords
This publication has 30 references indexed in Scilit:
- Effects of Estrogens on the Testosterone Levels of peripheral and Spermatic Vein Blood in Patients With Prostatic CancerJournal of Urology, 1979
- Plasma testosterone in patients receiving diethylstilbestrolUrology, 1978
- Hormone Changes in Patients with Prostatic Carcinoma, During Treatment with Estramustine PhosphateJournal of Urology, 1977
- Subcapsular Orchidectomy for Carcinoma of the Prostate1British Journal of Urology, 1977
- SEX HORMONE BINDING GLOBULIN BINDING CAPACITY, TESTOSTERONE, 5α-DIHYDROTESTOSTERONE, OESTRADIOL AND PROLACTIN IN PLASMA OF PATIENTS WITH PROSTATIC CARCINOMA UNDER VARIOUS TYPES OF HORMONAL TREATMENTActa Endocrinologica, 1977
- Hormonal Pattern in Prostatic Carcinoma following Orchidectomy: 5-Year Follow-upBritish Journal of Urology, 1977
- The Assessment of Results Following Endocrine Therapy for Prostatic CancerJournal of Urology, 1975
- SOME ASPECTS OF THE EFFECT OF CYPROTERONE ACETATE ON LEVELS OF OTHER STEROID HORMONES IN MANReproduction, 1974
- The veterans administration cooperative urological research group's studies of cancer of the prostateCancer, 1973
- Der Einfluß von Cyproteronacetat auf die Testosteron-Biosynthese im RattenhodenHoppe-Seyler´s Zeitschrift Für Physiologische Chemie, 1971