A Regioselective Synthesis of Azafluorenone Alkaloids1
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (02) , 95-96
- https://doi.org/10.1055/s-1991-20639
Abstract
6-Methoxyonychine 2 (8-methoxy-4-methyl-5H-indeno[1,2-b]pyridin-5-one) is obtained regioselectively from the biaryl 9 [2-(2-bromo-5-methoxyphenyl)-4-methyl-3-pyridinecarboxylic acid] via a Parham-type cyclisation. Alternatively, 9 can be converted to the unnatural isomer 8-methoxyonychine 11 by a simple two-step procedure (cyclisation and debromination).Keywords
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