Effects of heavy metals instilled intratracheally into rats. I. Dose-dependent uptake of cadmium chloride by the lung and its transfer to the liver.

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Abstract
Uptake and absorption of cadmium (Cd) through the airway were examined by determining the dose-dependent accumulation in the lung and its transfer to other organs after a single intratracheal instillation of cadmium chloride into rats. Male rats of the Wistar strain (10 weeks old; body weight, 270 .+-. 10g (mean.+-.S.D.)) were instilled with Cd dissolved in 0.4 ml saline at eight doses (0.313.sbd.40.mu.g Cd/rat) and killed two days later. Concentrations (.mu.g/g tissue) and contents (.mu.g/tissue) of Cd in the lung, liver, kidney and spleen were determined by flameless Zeeman atomic absorption spectrophotometry and/or inductively coupled argon plasma-atomic emission spectrometry (ICP). More than 90% of Cd were accumulated in the lung when the dose was lower than 2.5 .mu.g Cd/rat, while the percentage of Cd accumulated in the lung decreased steeply at higher doses than 5 .mu.g Cd/rat and the metal was transferred predominantly to the liver.

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