The Molecular Basis of Acute Gout

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Abstract
The mechanisms whereby the urate crystal initiates the acute attack of gout have been sought for more than a century; critical experiments are described through which it has been established that after the crystal's ingestion by the cell, hydrogen bonding occurs between crystal and lysosomal membrane. The result is membrane rupture, release of lysosomal enzymes, cell autolysis, and discharge of enzymes into joint fluid.

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