Calcitonin and Parathyroid Hormone – Relation to Early Neonatal Hypocalcemia in Infants of Diabetic Mothers

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Abstract
The levels of total and ultrafiltrable calcium, phosphorus, total protein, calcitonin (CT) and parathyroid hormone (PTH) in plasma were determined together with blood sugar in 11 consecutive cases of infants of diabetic mothers (IDM) and 9 healthy term infants during the first days of life. The decrease of calcium in plasma after birth was significantly greater in IDM than in controls. In both IDM and controls, a marked increase of the CT concentration was observed after birth. The maximum was reached at 24 h of age. No significant differences were seen between the two groups. Only in IDM was a significant correlation between calcium and CT in plasma seen, suggesting a greater sensitivity to CT in these infants. Low values of PTH in comparison with adult standards were found in both groups of infants, despite decreasing calcium levels. A hypothesis is presented to account for early neonatal hypocalcemia (NHC) in IDM.

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