Catatonia after Epidural Morphine

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Abstract
A 43‐year‐old male with bronchogenic carcinoma was treated with continuous epidural morphine via a thoracic epidural catheter. On the fifth day, after a total dose of 24 mg morphine chloride in 10 or 20 ml saline, he developed hallucinations, hyperthermia, spasticity, narcolepsy and opisthotonos. Respiratory rate and blood pressure were unaffected. Intravenous naloxone reversed all neurological abnormalities. This unusual syndrome was probably caused by a rostral spread of morphine. The location of the catheter and volume seem to be important variables. Hallucinations are important signs of impencling intoxication.