The Acute Effect of Some Chlorinated Hydrocarbon Insecticides on the Acetylcholine Content of Rat Brain
- 1 January 1971
- journal article
- Published by Canadian Science Publishing in Canadian Journal of Physiology and Pharmacology
- Vol. 49 (1) , 79-83
- https://doi.org/10.1139/y71-010
Abstract
Changes in total brain acetylcholine (ACh) levels as related to convulsive activity were followed after the intracarotid administration of four structurally unrelated chlorinated hydrocarbon insecticides to rats. ACh levels were determined by gas chromatography. The level of ACh found in cannulated controls was 4.7 ± 0.5 (S.E.M.) μg/g fresh tissue. Lindane raised the ACh level (μg/g) to 3.5–6.7, dieldrin to 8.5–9.7, heptachlor to 6.5–10.7, and DDT to 8.8–10.9. The order of neurotoxic signs was lindane > dieldrin > heptachlor > DDT.Keywords
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