Cytokines in multiple sclerosis: pro-inflammation or pro-remyelination?
- 1 June 1998
- journal article
- review article
- Published by SAGE Publications in Multiple Sclerosis Journal
- Vol. 4 (3) , 169-173
- https://doi.org/10.1177/135245859800400315
Abstract
The targets of the inflammatory response in multiple sclerosis (MS) are myelin and the myelin producing cells, oligodendrocytes. The infiltration of activated immune cells and recruitment of endogenous glia lead to the destruction of myelin and oligodendrocytes, a process that is compounded by the release of cytokines by infiltrating cells. Recent evidence suggests that key cytokines that are responsible for the destruction of myelin may also mediate the process of remyelination and repair. It appears that both inflammatory and repair processes are governed by the temporal and spatial relation of cytokines to their targets.Keywords
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