Safety and Immunogenicity in Neonatal Mice of a HyperattenuatedListeriaVaccine Directed against Human Immunodeficiency Virus
Open Access
- 15 January 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (2) , 918-922
- https://doi.org/10.1128/jvi.76.2.918-922.2002
Abstract
CD8+T cells are a major component of the adaptive response of a host to infections by viruses and other intracellular pathogenic agents. However, because of the intrinsic immaturity of the immune system of neonatal animals, neonates are highly sensitive to a variety of pathogens and may be unable to respond in a protective manner. Here we explore whether a hyperattenuated strain ofListeria monocytogenesthat can be used as a live vaccine vector in adults is safe and able to induce an effective response in neonates. We answer both questions affirmatively.Keywords
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