Long-Term Intravenous Administration of Fat Emulsions in Dogs and Single Infusions in Man

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Abstract
The effects of the chronic administration of several intravenous fat emulsions to normal dogs have been studied. The emulsions were administered in larger amounts than is generally recommended for man in order to study any latent toxicity and thus test the safety of the emulsions. Some major effects noted following multiple infusions of fat include lethargy, anorexia, weight loss, vomiting, lipemia, anemia and leukocytosis. The incidence and severity of these effects varied with the emulsions. An experimental SR emulsion was given to clinical patients, but discontinued after ill effects were noted. The new SR-151 emulsion was found to be the best tolerated emulsion in dogs. The side effects encountered with this emulsion were minimal even after multiple infusions of 8 gm. fat per kg. per day.