Cytotoxic Prenylxanthones from Garcinia bracteata
- 10 March 2000
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 63 (4) , 441-446
- https://doi.org/10.1021/np9903088
Abstract
Bioassay-guided fractionation of a leaf extract of G. bracteata has yielded six new prenylxanthones, bractatin (1), isobractatin (2), 1-O-methylbractatin (3), 1-O-methylisobractatin (4), 1-O-methyl-8-methoxy-8,8a-dihydrobractatin (5), and 1-O-methylneobractatin (6). The structures of these compounds have been elucidated by spectroscopic means (NMR, MS), literature data, and X-ray crystallographic analysis of 2. These compounds possess significant cytotoxicity against the KB cell line.Keywords
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