ERYSIPELAS ARTHRITIS IN SWINE - LYSOSOMAL ENZYME LEVELS IN SYNOVIAL-FLUIDS

  • 1 January 1976
    • journal article
    • research article
    • Vol. 37  (3) , 295-298
Abstract
Arthritic and histologically normal joints from swine in which arthritis was produced by the i.v. inoculation of E. rhusiopathiae were used as a source of fluids for lysosomal enzyme determinations. Mean lysozyme activities in synovias from arthritic and histologically normal joints were 16.60 and 5.79 .mu.g/ml, respectively. Acid phosphatase (ACP) was increased > 8 times the activity in histologically normal joints; there was no relationship between lysozyme and ACP, indicating the probability that 1 enzyme came from another source. The cytoplasmic enzyme lactic dehydrogenase (LDH) was increased in proportion to ACP, indicating that cell death and not selective extrusion of lysosomal enzymes during phagocytosis was an important mechanism of enzyme release in arthritic joints. Lysozyme activities in synovias from histologically normal joints were often increased above campanion serum concentrations, indicating the enzyme has a special role in the joint. The ratio of activities of lysozyme to ACP in pig buffy coat lysates was different from the ratio of the 2 enzymes in synovias from arthritic joints. [This disease has several clinical and morphologic similarities to rheumatoid arthritis in man.].

This publication has 1 reference indexed in Scilit: