Effects of cyclosporin A on active Crohn’s disease
- 1 February 1989
- journal article
- clinical trial
- Published by Springer Nature in Gastroenterologia Japonica
- Vol. 24 (1) , 12-15
- https://doi.org/10.1007/bf02774864
Abstract
Seven patients with active Crohn’s disease were treated with cyclosporin A orally for 16 weeks. The initial dose was 8 mg/kg/day and the subsequent dose was adjusted to maintain the plasma concentration of cyclosporin A of approximately 200 ng/ml. The mean value of the Crohn’s disease activity index before treatment was 194.3±57.4. It was gradually decreased reaching a nadir at 12 weeks (139.0±45.6, p< 0.05) and one enterocutaneous fistula was closed. White blood cell counts, hemoglobin and α-2-globulin did not significantly improve during treatment. Cyclosporin A could be indicated when steroids, sulfasalazine or azathioprine are not effective or not tolerated.Keywords
This publication has 13 references indexed in Scilit:
- Cyclosporin treatment for rheumatoid arthritis: a placebo controlled, double blind, multicentre study.Annals of the Rheumatic Diseases, 1986
- Cyclosporin A (CyA) in primary Sjögren's syndrome: a double blind study.Annals of the Rheumatic Diseases, 1986
- CYCLOSPORIN INCREASES THE RATE AND LENGTH OF REMISSIONS IN INSULIN-DEPENDENT DIABETES OF RECENT ONSETThe Lancet, 1986
- Cyclosporine Monitoring and Pharmacokinetics in Pediatrie Liver Transplant Patients1985
- Morbus Crohn: erste Erfahrungen mit Cyclosporin A bei einer AdoleszentenDeutsche Medizinische Wochenschrift (1946), 1985
- CYCLOSPORIN IN ULCERATIVE COLITISThe Lancet, 1984
- CYCLOSPORIN FOR CROHN'S DISEASEThe Lancet, 1984
- HIGH DOSE METHYLPREDNISOLONE INCREASES PLASMA CYCLOSPORIN LEVELS IN RENAL TRANSPLANT RECIPIENTSThe Lancet, 1984
- CYCLOSPORIN IMPROVES GRAVES' OPHTHALMOPATHYThe Lancet, 1983
- TREATMENT OF INTRAOCULAR INFLAMMATORY DISEASE WITH CYCLOSPORIN AThe Lancet, 1983