Inhibition of simian immunodeficiency virus (SIV) replication by CD8 + cells of SIV‐infected rhesus macaques: Implications for immunopathogenesis

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Abstract
The ability of the CD8 + cells from simian immunodeficiency virus (SIV)‐infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat‐stable soluble factor of molecular size greater than 10kDa. CD8 + supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8 + cell‐mediated cell killing may therefore account for DC4 + cell depletion in certain SIV‐infected macaques.