Sodium ions increase the affinity of clonidine for ?1-adrenoceptors in rat brain
- 1 June 1980
- journal article
- research article
- Published by Springer Nature in Naunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie
- Vol. 312 (2) , 105-106
- https://doi.org/10.1007/bf00569717
Abstract
α1-Adrenoceptors in rat brain membranes, labeled by the antagonist [3H] prazosin, increase their affinity for clonidine several-fold when sodium ions are added. The conversion of α1-adrenoceptors, by sodium ion, into a conformation, which has higher affinity for the agonist clonidine, indicates that these receptors as the α2-adrenoceptors are modulated by cations in vitro.Keywords
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