Treatment of Bacteroides fragilis Bacteremia with Clindamycin

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Abstract
Eight patients with Bacteroides fragilis bacteremia were treated with iv clindamycin. All patients had abdominal surgical disease (four patients) or decubitus ulcers (four patients), and six of them had had antibiotic treatment just before or at the time of bacteremia. Seven patients had favorable clinical and bacteriologic responses to treatment, particularly those who underwent prompt drainage or debridement of localized purulent or necrotic lesions. The eighth patient had a transient bacteremia, and the efficacy of treatment could not be evaluated. Clindamycin is the most active antibiotic in vitro against B. fragilis and is an effective agent in the treatment of B. fragilis bacteremia.

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