Enzyme Activities in Human Gastric Mucosa in Gastritis and Resected Stomachs

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Abstract
Biopsy specimens from the antral and body part of the stomach were studied for a range of marker enzymes in 11 patients with superficial gastritis, 9 patients with atrophic gastritis, and 31 Billroth-II-resected patients and compared with activities found in controls with normal gastric mucosa. In the antral part of the stomach increased .gamma.-glutamyltransferase activity was found in superficial (p < 0.01) and atrophic gastritis (p < 0.05), whereas monoamine oxidase activity was decreased in superficial (p < 0.01) and atrophic gastritis (p < 0.05). In the body part, increased activity of .gamma.-glutamyltransferase (p < 0.01) and acid-.beta.-glucuronidase (p < 0.01) was found in superficial gastritis. In atrophic gastritis increased activities for lactase (p < 0.01), alkaline phosphatase (p < 0.05), leucyl-.beta.-naphthylamidase (p < 0.05), .gamma.-glutamyltransferase (p < 0.01), 5''-nucleotidase (p < 0.01), N-acetyl-.beta.-D-glucosaminidase (p < 0.05), and acid-.beta.-glucuronidase (p < 0.01) were found. Specimens from the gastric remnant showed an enzyme activity pattern similar to that seen in the body in atrophic gastritis, apart from a significantly decreased monoamine oxidase activity (p < 0.004). Specimens with dysplasia in the gastric remnant showed decreased monoamine oxidase activity when compared with specimens without dysplasia (p < 0.01).