SHOCK LIVER

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  • 1 January 1978
    • journal article
    • research article
    • Vol. 204  (5) , 417-421
Abstract
Severe heart disease in 5 patients resulted in cardiogenic shock of > 24 h duration. As a sequela to the shock, severe liver affection occurred. Serum aspartate aminotransferase and serum lactate dehydrogenase showed very high activities. The prothrombin-proconvertin index was reduced to < 25% of normal. Four patients were jaundiced. The condition gave rise to differential diagnostic problems. Liver biopsies were available from 4 patients and histological examination of an autopsy specimen of the liver was performed in each case. The liver histology showed centrilobular necrosis and hemorrhage in all patients. Centrilobular fibrosis apparently develops later in the condition. The pathogenesis of this liver affection is probably hypoxic injury to the centrilobular areas of the liver lobule due to reduced liver blood flow.

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