Hepatitis, Exfoliative Dermatitis and Abnormal Bone Marrow Occurring during Tridione Therapy

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Abstract
SINCE 1944, when Everett and Richards1 described the anticonvulsive action of tridione (3, 5, 5-trimethyloxazolidine-2, 4-dione), the drug has been used in human beings to control epileptic attacks, especially petit mal seizures. Varying toxic reactions have been described, but to our knowledge this is the first case in which hepatic dysfunction, severe exfoliative dermatitis and leukemoid bone-marrow changes have been reported in the same patient.The first report on the clinical use of the drug made very little mention of toxic reactions or unpleasant side effects. In 1945 Lennox2 noted that in the majority of adolescent or adult patients, but . . .
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