Effects of β-Adrenoreceptor Blocking Drugs on Plasma Volume, Renin and Aldosterone as Components of Their Antihypertensive Action
- 1 January 1976
- journal article
- clinical trial
- Published by Springer Nature in Drugs
- Vol. 11 (Supplement) , 156-163
- https://doi.org/10.2165/00003495-197600111-00032
Abstract
In young males with essential hypertension, propranolol and pindolol in small doses caused significant expansion of plasma volume (PV) after one month which did not prevent a reduction in BP. With higher doses, changes in PV were inconsistent and reductions in plasma renin activity (PRA) and 24- hour aldosterone excretion (AE) not closely related to BP changes. The effects of β-adrenoreceptor blocking drugs on PV, PRA and AE do not appear to be important components of their anti-hypertensive actionKeywords
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