A Useful Method for the Dealkylation of Dialkyl Phosphonates

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Abstract
The conversion of dialkyl phosphonates (1) to phosphonic acids (2) is usually accomplished by heating 1 in concentrated HC1 or HBr.1 This method, however, is subject to interference by other functional groups. In connection with our synthetic studies on biologically active organophosphorus compounds, we were faced with the problem of effecting the dealkylation of 1 containing labile functional groups under mild conditions. At the time when we were engaged in this study, the only available method for this purpose was to heat 1 in chlorotrimethylsilane2. This reaction, albeit mild, takes several days and the yields are not always satisfactory. We wish to report a very mild and extremely efficient method for the dealkylation of 1. Our strategy for effect-

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