Determination of Tricyclic Antidepressants by High-Performance Liquid Chromatography
- 1 January 1981
- journal article
- research article
- Published by Oxford University Press (OUP) in Journal of Analytical Toxicology
- Vol. 5 (1) , 20-23
- https://doi.org/10.1093/jat/5.1.20
Abstract
A method is described for the determination of amitriptyline, nortriptyline, imipramine and desipramine at low nanogram concentrations in serum. Separation and quantitation are performed by reversed-phase, isocratic, high-performance liquid chromatography utilizing ultraviolet detection at 210 nm. An internal standard, chloramitriptyline, is used as an aid to quantitation. Recovery of all four tricyclics is greater than 84%. The relative standard deviation for the analysis of amitriptyline, nortriptyline, imipramine and desipramine is less than 8% at a concentration of 100 ng/mL.This publication has 22 references indexed in Scilit:
- Rapid, sensitive gas-liquid chromatographic method for determination of amitriptyline and nortriptyline in plasma using a nitrogen-sensitive detectorJournal of Chromatography A, 1977
- Therapeutic monitoring of tricyclic antidepressants in plasma by gas chromatography.Clinical Chemistry, 1977
- Quantitation of amitriptyline and nortriptyline in human serumJournal of Chromatography B: Biomedical Sciences and Applications, 1977
- Simultaneous measurement of secondary and tertiary tricyclic antidepressants by GC/MS chemical ionization mass fragmentography.Clinical Chemistry, 1977
- Assay of tricyclic structured drugs and their metabolites in urine by high- performance liquid chromatographyJournal of Chromatography A, 1977
- Quantitative determination of amitriptyline and nortriptyline in plasma by high-performance liquid chromatographyJournal of Chromatography A, 1977
- Quantitative Determination of Amitriptyline and Its Principal Metabolite, Nortriptyline, by GLC‐Chemical Ionization Mass SpectrometryJournal of Pharmaceutical Sciences, 1977
- Gas-chromatographic analysis for therapeutic concentration of imipramine and disipramine in plasma, with use of a nitrogen detector.Clinical Chemistry, 1976
- Gas-chromatographic analysis for therapeutic concentrations of amitriptyline and nortriptyline in plasma, with use of a nitrogen detector.Clinical Chemistry, 1976
- Electron beam ionization mass fragmentographic analysis of tricyclic antidepressants in human plasmaJournal of Pharmaceutical Sciences, 1976