Handling of Large Experimental Animals Infected with a Risk Group 4 Virus

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Abstract
The safe experimental handling of animals infected with a new Risk Category 4 virus posed significant biosafety challenges. Novel approaches for restraining, handling and inoculating horses, cats and large fruit-eating bats with equine morbillivirus were developed. Equipment was designed to allow staff working in encapsulating suits access to all parts of a large animal room capable of accommodating seven horses individually. Procedures were developed for the safe handling, anesthesia and euthanasia of experimental animals and for the disposal of infected horse carcasses. Comprehensive staff training for this demanding work included safety consciousness, teamwork and training in first aid and emergency procedures.